loading...| Preferred Name | Tamoxifen Citrate | |
| Synonyms |
(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate Tamoxifen Citrate Tamoxifen citrate Tamoxifeni Citras 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate tamoxifen citrate Gen-Tamoxifen (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate Dignotamoxi PMS-Tamoxifen Novo-Tamoxifen TAMOXIFEN CITRATE Apo-Tamox Clonoxifen Ebefen Emblon Estroxyn Fentamox Genox ICI 46,474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex Nolvadex-D Nourytam Novofen Noxitem Oestrifen Oncotam Soltamox TAM Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Zemide |
|
| Definitions |
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C855 |
|
| Accepted_Therapeutic_Use_For |
Breast cancer; Endometrial cancer; Gynecomastia; Melanoma; Ovarian cancer |
|
| ALT_DEFINITION |
A drug used to treat certain types of breast cancer in women and men. It is also used to prevent breast cancer in women who have had ductal carcinoma in situ (abnormal cells in the ducts of the breast) and in women who are at a high risk of developing breast cancer. Tamoxifen citrate is also being studied in the treatment of other types of cancer. It blocks the effects of the hormone estrogen in the breast. Tamoxifen citrate is a type of antiestrogen. |
|
| CAS_Registry |
54965-24-1 |
|
| CHEBI_ID |
CHEBI:9397 |
|
| Chemical_Formula |
C26H29NO.C6H8O7 |
|
| code |
C855 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma and other cancers that overexpress PKC. |
|
| Display_Name |
Tamoxifen Citrate |
|
| FDA_UNII_Code |
7FRV7310N6 |
|
| FULL_SYN |
(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate Tamoxifen Citrate Tamoxifen citrate Tamoxifeni Citras 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene Citrate tamoxifen citrate Gen-Tamoxifen (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate Dignotamoxi PMS-Tamoxifen Novo-Tamoxifen TAMOXIFEN CITRATE Apo-Tamox Clonoxifen Ebefen Emblon Estroxyn Fentamox Genox ICI 46,474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex Nolvadex-D Nourytam Novofen Noxitem Oestrifen Oncotam Soltamox TAM Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Zemide |
|
| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Tamoxifen Citrate |
|
| Legacy Concept Name |
Tamoxifen |
|
| Maps_To |
Tamoxifen Citrate |
|
| NCI_Drug_Dictionary_ID |
42901 |
|
| NSC Number |
180973 |
|
| PDQ_Closed_Trial_Search_ID |
42901 |
|
| PDQ_Open_Trial_Search_ID |
42901 |
|
| Preferred_Name |
Tamoxifen Citrate |
|
| prefixIRI |
Thesaurus:C855 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0700621 |
|
| subClassOf |