loading...| Preferred Name | Glasdegib | |
| Synonyms |
PF 04449913 PF-04449913 GLASDEGIB Glasdegib PF04449913 |
|
| Definitions |
An orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Glasdegib appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84862 |
|
| CAS_Registry |
1095173-27-5 |
|
| code |
C84862 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Glasdegib appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies. |
|
| Display_Name |
Glasdegib |
|
| FDA_UNII_Code |
K673DMO5H9 |
|
| FULL_SYN |
PF 04449913 PF-04449913 GLASDEGIB Glasdegib PF04449913 |
|
| Has_Salt_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Glasdegib |
|
| Maps_To |
Glasdegib |
|
| NCI_META_CUI |
CL412426 |
|
| Preferred_Name |
Glasdegib |
|
| prefixIRI |
Thesaurus:C84862 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| subClassOf |