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National Cancer Institute Thesaurus
| Preferred Name | Tocilizumab | |
| Synonyms |
IL-6 receptor monoclonal antibodies: tocilizumab Tocilizumab Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer TOCILIZUMAB Actemra MRA R-1569 RoActemra |
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| Definitions |
A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. IL-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders, certain types of cancers and possibly various other inflammatory conditions. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84217 |
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| Accepted_Therapeutic_Use_For |
Treatment of COVID-19-emergency use authorization (EUA).
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| CAS_Registry |
375823-41-9
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| CHEBI_ID |
CHEBI:64360
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| code |
C84217
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191670 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191404 |
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| Contributing_Source |
ACC/AHA CTRP FDA GDC HemOnc
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| DEFINITION |
A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. IL-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders, certain types of cancers and possibly various other inflammatory conditions.
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| Display_Name |
Tocilizumab
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| FDA_UNII_Code |
I031V2H011
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|
| FULL_SYN |
IL-6 receptor monoclonal antibodies: tocilizumab Tocilizumab Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer TOCILIZUMAB Actemra MRA R-1569 RoActemra
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| Has_ACC-AHA_SARS2_Authorized_Value |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17998 |
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| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Tocilizumab
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|
| Maps_To |
Tocilizumab
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| NCI_Drug_Dictionary_ID |
713832
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| PDQ_Closed_Trial_Search_ID |
713832
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| PDQ_Open_Trial_Search_ID |
713832
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| Preferred_Name |
Tocilizumab
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| prefixIRI |
Thesaurus:C84217
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C1609165
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| subClassOf |
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