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National Cancer Institute Thesaurus
| Preferred Name | Lomitapide | |
| Synonyms |
BMS-201038-01 N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)Biphenyl-2-yl)Carbonyl)Amino)Piperidin-1-yl)Butyl)-9H-Fluorene-9-Carboxamide 9H-Fluorene-9-Carboxamide, N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)(1,1'-Biphenyl)-2-yl)Carbonyl)Amino)-1-Piperidinyl)Butyl)- AEGR-733 LOMITAPIDE Lomitapide |
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| Definitions |
A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein. Inhibition of MTP by lomitapide blocks transfer of lipid to apo-B, and as a result emerging apo-B is destroyed and lipoprotein secretion is inhibited. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C83891 |
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| CAS_Registry |
182431-12-5
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| Chemical_Formula |
C39H37F6N3O2
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| code |
C83891
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
A small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein. Inhibition of MTP by lomitapide blocks transfer of lipid to apo-B, and as a result emerging apo-B is destroyed and lipoprotein secretion is inhibited.
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| FDA_UNII_Code |
82KUB0583F
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| FULL_SYN |
BMS-201038-01 N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)Biphenyl-2-yl)Carbonyl)Amino)Piperidin-1-yl)Butyl)-9H-Fluorene-9-Carboxamide 9H-Fluorene-9-Carboxamide, N-(2,2,2-Trifluoroethyl)-9-(4-(4-(((4'-(Trifluoromethyl)(1,1'-Biphenyl)-2-yl)Carbonyl)Amino)-1-Piperidinyl)Butyl)- AEGR-733 LOMITAPIDE Lomitapide
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| Has_Salt_Form | ||
| label |
Lomitapide
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| Preferred_Name |
Lomitapide
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| prefixIRI |
Thesaurus:C83891
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C2827241
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| subClassOf |
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