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National Cancer Institute Thesaurus
| Preferred Name | Linagliptin | |
| Synonyms |
1H-Purine-2,6-dione, 8-((3R)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)- LINAGLIPTIN (R)-8-(3-Amino-Piperidin-1-yl)-7-but-2-ynyl-3-Methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 8-((3R)-3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-3,7-Dihydro-1H-Purine-2,6-Dione Linagliptin BI 1356 BS BI-1356 Tradjenta |
|
| Definitions |
A potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. The inhibition of DPP-4 by linagliptin appears to be longer lasting than that by some other DPP-4 inhibitors tested. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C83887 |
|
| Accepted_Therapeutic_Use_For |
Diabetes Mellitus Type II
|
|
| CAS_Registry |
668270-12-0
|
|
| Chemical_Formula |
C25H28N8O2
|
|
| code |
C83887
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 |
|
| Contributing_Source |
FDA GDC
|
|
| DEFINITION |
A potent, orally bioavailable dihydropurinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. The inhibition of DPP-4 by linagliptin appears to be longer lasting than that by some other DPP-4 inhibitors tested.
|
|
| FDA_UNII_Code |
3X29ZEJ4R2
|
|
| FULL_SYN |
1H-Purine-2,6-dione, 8-((3R)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)- LINAGLIPTIN (R)-8-(3-Amino-Piperidin-1-yl)-7-but-2-ynyl-3-Methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 8-((3R)-3-Aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-Methyl-1-((4-Methylquinazolin-2-yl)Methyl)-3,7-Dihydro-1H-Purine-2,6-Dione Linagliptin BI 1356 BS BI-1356 Tradjenta
|
|
| Is_Value_For_GDC_Property | ||
| label |
Linagliptin
|
|
| Maps_To |
Linagliptin
|
|
| NCI_Drug_Dictionary_ID |
793591
|
|
| PDQ_Closed_Trial_Search_ID |
793591
|
|
| PDQ_Open_Trial_Search_ID |
793591
|
|
| Preferred_Name |
Linagliptin
|
|
| prefixIRI |
Thesaurus:C83887
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C2746078
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| subClassOf |
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