National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Etidronate Disodium

Synonyms

Etidronate Disodium

Disodium Dihydrogen (1-hydroxyethylidene)bis(phosphonate)

ETIDRONATE DISODIUM

Calcimux

Didronel

Diphos

Etidron

Definitions

A synthetic therapeutic diphosphonate analogue of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, etidronate disodium differs from endogenous pyrophosphate in its resistance to enzymatic hydrolysis. This agent adsorbs to hydroxyapatite cells and reduces the number of osteoclasts, thereby inhibiting abnormal bone resorption. Etidronate may also directly stimulate bone formation by osteoblasts. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C831

Accepted_Therapeutic_Use_For

hypercalcemia of malignancy.

CAS_Registry

7414-83-7

Chemical_Formula

C2H6O7P2.2Na

code

C831

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic therapeutic diphosphonate analogue of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, etidronate disodium differs from endogenous pyrophosphate in its resistance to enzymatic hydrolysis. This agent adsorbs to hydroxyapatite cells and reduces the number of osteoclasts, thereby inhibiting abnormal bone resorption. Etidronate may also directly stimulate bone formation by osteoblasts. (NCI04)

FDA_UNII_Code

M16PXG993G

FULL_SYN

Etidronate Disodium

Disodium Dihydrogen (1-hydroxyethylidene)bis(phosphonate)

ETIDRONATE DISODIUM

Calcimux

Didronel

Diphos

Etidron

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1332

label

Etidronate Disodium

Legacy Concept Name

Etidronate_Disodium

Preferred_Name

Etidronate Disodium

prefixIRI

Thesaurus:C831

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0037507

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C443

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67439

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