National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Dabrafenib
Synonyms

GSK-2118436

Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-

BRAF Inhibitor GSK2118436

GSK-2118436A

DABRAFENIB

Dabrafenib

GSK2118436

Definitions

An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82386

Accepted_Therapeutic_Use_For

metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation

CAS_Registry

1195765-45-7

Chemical_Formula

C23H20F3N5O2S2

code

C82386

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations.

Display_Name

Dabrafenib

FDA_UNII_Code

QGP4HA4G1B

FULL_SYN

GSK-2118436

Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-

BRAF Inhibitor GSK2118436

GSK-2118436A

DABRAFENIB

Dabrafenib

GSK2118436

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128059

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17476

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Dabrafenib

Legacy Concept Name

BRAF_Inhibitor_GSK2118436

Maps_To

Dabrafenib

NCI_Drug_Dictionary_ID

641977

PDQ_Closed_Trial_Search_ID

641977

PDQ_Open_Trial_Search_ID

641977

Preferred_Name

Dabrafenib

prefixIRI

Thesaurus:C82386

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C3467876

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155322

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_75045 OBA LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026237 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/C561627 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/1424911 RXNORM LOOM
http://purl.jp/bio/4/id/201506005799635395 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_75045 CHEBI LOOM
https://go.drugbank.com/drugs/DB08912 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/015042 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000187069 NDFRT LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000641977 PDQ LOOM
http://purl.obolibrary.org/obo/NCIT_C82386 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C82386 MELO LOOM
http://stirdf.jst.go.jp/id/201307064444622300 IOBC LOOM
http://www.drugbank.ca/drugs/DB08912 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4032496 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/703641001 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/L01EC02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C561627 RH-MESH LOOM