loading...| Preferred Name |
Liraglutide |
|
| Synonyms |
LIRAGLUTIDE Liraglutide N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide NN2211 Victoza |
|
| Definitions |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82239 |
|
| CAS_Registry |
204656-20-2 |
|
| Chemical_Formula |
C172H265N43O51 |
|
| code |
C82239 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. |
|
| Display_Name |
Liraglutide |
|
| FDA_UNII_Code |
839I73S42A |
|
| FULL_SYN |
LIRAGLUTIDE Liraglutide N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide NN2211 Victoza |
|
| label |
Liraglutide |
|
| Legacy Concept Name |
Liraglutide |
|
| NCI_Drug_Dictionary_ID |
775374 |
|
| PDQ_Closed_Trial_Search_ID |
775374 |
|
| PDQ_Open_Trial_Search_ID |
775374 |
|
| Preferred_Name |
Liraglutide |
|
| prefixIRI |
Thesaurus:C82239 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1456408 |
|
| subClassOf |