National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Prasugrel
Synonyms

PRASUGREL

Prasugrel

Definitions

An orally bioavailable thienopyridine, with antiplatelet activity. Upon oral administration, the active metabolite of prasugrel targets and irreversibly binds to the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor. This inhibits ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81566

CAS_Registry

150322-43-3

Chemical_Formula

C20H20FNO3S

code

C81566

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

HemOnc

DEFINITION

An orally bioavailable thienopyridine, with antiplatelet activity. Upon oral administration, the active metabolite of prasugrel targets and irreversibly binds to the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor. This inhibits ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, fibrinogen binding to platelets and platelet adhesion and aggregation. This results in increased bleeding time.

Display_Name

Prasugrel

FDA_UNII_Code

34K66TBT99

FULL_SYN

PRASUGREL

Prasugrel

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C81571

label

Prasugrel

Legacy Concept Name

Prasugrel

Preferred_Name

Prasugrel

prefixIRI

Thesaurus:C81566

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1620287

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80483

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_87715 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000179815 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C81566 BERO LOOM
http://purl.bioontology.org/ontology/ATC/B01AC22 ATC LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#prasugrel SDO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025415 PMAPP-PMO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01072 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01072 MIO LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01072 MIO LOOM
http://purl.obolibrary.org/obo/dinto_DB06209 DINTO LOOM
http://www.drugbank.ca/drugs/DB06209 FTC LOOM
http://purl.bioontology.org/ontology/RXNORM/613391 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_87715 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_87715 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_87715 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_87715 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_87715 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_87715 DDSS LOOM
http://purl.bioontology.org/ontology/VANDF/4029056 VANDF LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Prasugrel SEPON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C408153 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/012994 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/443129001 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB06209 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LA28653-6 LOINC LOOM