National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Sugammadex

Synonyms

SUGAMMADEX

Sugammadex

Definitions

A biologically inert, selective relaxant binding agent (SRBA) composed of a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, such as rocuronium and vecuronium, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80629

CAS_Registry

343306-71-8

Chemical_Formula

C72H112O48S8

code

C80629

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A biologically inert, selective relaxant binding agent (SRBA) composed of a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, such as rocuronium and vecuronium, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade.

Display_Name

Sugammadex

FDA_UNII_Code

361LPM2T56

FULL_SYN

SUGAMMADEX

Sugammadex

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78123

label

Sugammadex

Legacy Concept Name

Sugammadex

Preferred_Name

Sugammadex

prefixIRI

Thesaurus:C80629

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1700695

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26170

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