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National Cancer Institute Thesaurus
| Preferred Name | Flucloxacillin | |
| Synonyms |
Floxacillin FLUCLOXACILLIN 6-(3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin Flucloxacillin BRL 2039 |
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| Definitions |
A narrow-spectrum, semisynthetic isoxazolyl penicillin with antibacterial activity. Floxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80591 |
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| CAS_Registry |
5250-39-5
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| CHEBI_ID |
CHEBI:5098
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| Chemical_Formula |
C19H17ClFN3O5S
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| code |
C80591
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
A narrow-spectrum, semisynthetic isoxazolyl penicillin with antibacterial activity. Floxacillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.
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| FDA_UNII_Code |
43B2M34G2V
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| FULL_SYN |
Floxacillin FLUCLOXACILLIN 6-(3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillin Flucloxacillin BRL 2039
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|
| label |
Flucloxacillin
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| Legacy Concept Name |
Floxacillin
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| Preferred_Name |
Flucloxacillin
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| prefixIRI |
Thesaurus:C80591
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0016267
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| subClassOf |
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