Link to this page
National Cancer Institute Thesaurus
| Preferred Name | Zopiclone | |
| Synonyms |
(+-)-Zopiclone 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl Ester 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine Amoban Imovane RP 27267 ZOPICLONE Zimovane Zopiclone |
|
| Definitions |
The racemic form of a nonbenzodiazepine, cyclopyrrolone with hypnotic and sedative activity and without significant anxiolytic activity. Although the exact mechanism of action remains to be fully elucidated, zopiclone is able to bind to and activate the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous system (CNS). This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This eventually leads to a hypnotic effect and allows for an induction of sleep. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80279 |
|
| CAS_Registry |
43200-80-2
|
|
| CHEBI_ID |
CHEBI:32315
|
|
| Chemical_Formula |
C17H17ClN6O3
|
|
| code |
C80279
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The racemic form of a nonbenzodiazepine, cyclopyrrolone with hypnotic and sedative activity and without significant anxiolytic activity. Although the exact mechanism of action remains to be fully elucidated, zopiclone is able to bind to and activate the omega-1 subtype of the alpha subunit of the gamma-aminobutyric acid-benzodiazepine GABA receptor complex (GABA-A), a chloride ionophore complex in the central nervous system (CNS). This leads to the opening of chloride channels, causing hyperpolarization, inhibition of neuronal firing, and enhancement of the inhibitory effect of GABA. This eventually leads to a hypnotic effect and allows for an induction of sleep.
|
|
| FDA_UNII_Code |
03A5ORL08Q
|
|
| FULL_SYN |
(+-)-Zopiclone 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl Ester 6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine Amoban Imovane RP 27267 ZOPICLONE Zimovane Zopiclone
|
|
| label |
Zopiclone
|
|
| Legacy Concept Name |
Zopiclone
|
|
| NCI_Drug_Dictionary_ID |
784213
|
|
| PDQ_Closed_Trial_Search_ID |
784213
|
|
| PDQ_Open_Trial_Search_ID |
784213
|
|
| Preferred_Name |
Zopiclone
|
|
| prefixIRI |
Thesaurus:C80279
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0078847
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |