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National Cancer Institute Thesaurus
Preferred Name | Copper Gluconate | |
Synonyms |
Cupric Gluconate Copper Gluconate COPPER GLUCONATE |
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Definitions |
The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations. |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80050 |
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CAS_Registry |
527-09-3
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Chemical_Formula |
2C6H11O7.Cu
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code |
C80050
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Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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Contributing_Source |
CTRP FDA GDC
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DEFINITION |
The orally bioavailable copper salt of D-gluconic acid. In addition to its roles as an enzyme cofactor for cytochrome C oxidase and superoxide dismutase, copper forms complexes with the thiocarbamate disulfiram (DSF) forming DSF-copper complexes, which enhances the DSF-mediated inhibition of the 26S proteasome; proteasome inhibition may result in inhibition of cellular protein degradation, cessation of cell cycle progression, inhibition of cellular proliferation, and the induction of apoptosis in susceptible tumor cell populations.
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Display_Name |
Copper Gluconate
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FDA_UNII_Code |
RV823G6G67
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FULL_SYN |
Cupric Gluconate Copper Gluconate COPPER GLUCONATE
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Has_Target | ||
Is_Value_For_GDC_Property | ||
label |
Copper Gluconate
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Legacy Concept Name |
Copper_Gluconate
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Maps_To |
Copper Gluconate
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NCI_Drug_Dictionary_ID |
614606
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PDQ_Closed_Trial_Search_ID |
614606
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PDQ_Open_Trial_Search_ID |
614606
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Preferred_Name |
Copper Gluconate
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prefixIRI |
Thesaurus:C80050
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Semantic_Type |
Pharmacologic Substance
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UMLS_CUI |
C0982097
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subClassOf |
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