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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Butoconazole | |
| Synonyms |
BUTOCONAZOLE (+-)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole Butoconazole RS 35887-10-3 |
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| Definitions |
A synthetic imidazole derivative with fungistatic properties. Butoconazole interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C79927 |
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| CAS_Registry |
64872-76-0
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|
| CHEBI_ID |
CHEBI:3240
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|
| Chemical_Formula |
C19H17Cl3N2S
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|
| code |
C79927
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A synthetic imidazole derivative with fungistatic properties. Butoconazole interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.
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| FDA_UNII_Code |
0Q771797PH
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|
| FULL_SYN |
BUTOCONAZOLE (+-)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole Butoconazole RS 35887-10-3
|
|
| Has_Salt_Form | ||
| label |
Butoconazole
|
|
| Legacy Concept Name |
Butoconazole
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|
| Preferred_Name |
Butoconazole
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|
| prefixIRI |
Thesaurus:C79927
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0054259
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| subClassOf |
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