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National Cancer Institute Thesaurus
| Preferred Name | Rivaroxaban | |
| Synonyms |
Rivaroxaban 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)- 1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide RIVAROXABAN BAY 59-7939 Xarelto |
|
| Definitions |
An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77995 |
|
| Accepted_Therapeutic_Use_For |
Deep Vein Thrombosis Prophylaxis
|
|
| CAS_Registry |
366789-02-8
|
|
| Chemical_Formula |
C19H18ClN3O5S
|
|
| code |
C77995
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc
|
|
| DEFINITION |
An orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.
|
|
| Display_Name |
Rivaroxaban
|
|
| FDA_UNII_Code |
9NDF7JZ4M3
|
|
| FULL_SYN |
Rivaroxaban 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)- 1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide RIVAROXABAN BAY 59-7939 Xarelto
|
|
| Is_Value_For_GDC_Property | ||
| label |
Rivaroxaban
|
|
| Legacy Concept Name |
Rivaroxaban
|
|
| Maps_To |
Rivaroxaban
|
|
| NCI_Drug_Dictionary_ID |
701565
|
|
| PDQ_Closed_Trial_Search_ID |
701565
|
|
| PDQ_Open_Trial_Search_ID |
701565
|
|
| Preferred_Name |
Rivaroxaban
|
|
| prefixIRI |
Thesaurus:C77995
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1739768
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|
| subClassOf |
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