loading...| Preferred Name |
Abiraterone |
|
| Synonyms |
Abiraterone ABIRATERONE 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol CB 7598 |
|
| Definitions |
A steroidal compound with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77333 |
|
| CAS_Registry |
154229-19-3 |
|
| Chemical_Formula |
C24H31NO |
|
| code |
C77333 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc OORO |
|
| DEFINITION |
A steroidal compound with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex; CYP17A1), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. |
|
| Display_Name |
Abiraterone |
|
| FDA_UNII_Code |
G819A456D0 |
|
| FULL_SYN |
Abiraterone ABIRATERONE 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol CB 7598 |
|
| Has_Salt_Form | ||
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Abiraterone |
|
| Legacy Concept Name |
Abiraterone |
|
| Maps_To |
Abiraterone |
|
| Preferred_Name |
Abiraterone |
|
| prefixIRI |
Thesaurus:C77333 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0754011 |
|
| subClassOf |