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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Alogliptin | |
| Synonyms |
Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)- pyrimidinyl]methyl]- ALOGLIPTIN Alogliptin |
|
| Definitions |
A selective, orally bioavailable, pyrimidinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. In addition to its effect on glucose levels, alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76906 |
|
| CAS_Registry |
850649-61-5
|
|
| Chemical_Formula |
C18H21N5O2
|
|
| code |
C76906
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A selective, orally bioavailable, pyrimidinedione-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. In addition to its effect on glucose levels, alogliptin may inhibit inflammatory responses by preventing the toll-like receptor 4 (TLR-4)-mediated formation of proinflammatory cytokines.
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|
| FDA_UNII_Code |
JHC049LO86
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|
| FULL_SYN |
Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)- pyrimidinyl]methyl]- ALOGLIPTIN Alogliptin
|
|
| Has_Salt_Form | ||
| label |
Alogliptin
|
|
| Legacy Concept Name |
Alogliptin
|
|
| NCI_Drug_Dictionary_ID |
733686
|
|
| PDQ_Closed_Trial_Search_ID |
733686
|
|
| PDQ_Open_Trial_Search_ID |
733686
|
|
| Preferred_Name |
Alogliptin
|
|
| prefixIRI |
Thesaurus:C76906
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|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1958126
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|
| subClassOf |
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