loading...| Preferred Name |
Iron Dextran |
|
| Synonyms |
IRON DEXTRAN Iron dextran Iron Dextran Iron Dextran Complex Iron Dextran Injection Dexferrum Ferrodex INFeD Imferon |
|
| Definitions |
A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran, used as a form of parenteral iron-replacement therapy. Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb). Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations. Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76837 |
|
| CAS_Registry |
9004-66-4 |
|
| Chemical_Formula |
HO(C6H10O5)n.Fe.3HO |
|
| code |
C76837 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 |
|
| Contributing_Source |
FDA HemOnc |
|
| DEFINITION |
A colloidal solution containing ferric oxyhydroxide complexed with polymerized dextran, used as a form of parenteral iron-replacement therapy. Upon administration and absorption, the iron dextran complex is removed from plasma by the reticuloendothelial system which cleaves it into the components iron and dextran; ferric iron subsequently binds to transferrin or is stored as hemosiderin or ferritin. Transferrin-bound iron is transported in the plasma to the liver, spleen and bone marrow, where is it is incorporated into hemoglobin (Hgb) and to muscle where it is incorporated into myoglobin (Mb). Use of this agent circumvents the gastrointestinal adverse effects commonly encountered with the use of orally administered iron salt preparations. Because of cross-reactivity with antibodies targeted against polysaccharides similar to dextran, anaphylactic reactions may occur with this type of iron formulation. |
|
| FDA_UNII_Code |
95HR524N2M |
|
| FULL_SYN |
IRON DEXTRAN Iron dextran Iron Dextran Iron Dextran Complex Iron Dextran Injection Dexferrum Ferrodex INFeD Imferon |
|
| label |
Iron Dextran |
|
| Legacy Concept Name |
Iron_Dextran |
|
| NCI_Drug_Dictionary_ID |
551718 |
|
| NCI_META_CUI |
CL387295 |
|
| NSC Number |
57682 |
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| Preferred_Name |
Iron Dextran |
|
| prefixIRI |
Thesaurus:C76837 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| subClassOf |