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National Cancer Institute Thesaurus
| Preferred Name | Enoxaparin Sodium | |
| Synonyms |
ENOXAPARIN SODIUM Enoxaparin Sodium Lovenox |
|
| Definitions |
The sodium salt of enoxaparin, a low molecular weight, synthetic heparin. As an anticoagulant/antithrombotic agent, enoxaprin's mechanism of action is similar to that of heparin, although it exhibits a higher ratio of anti-Factor Xa to anti-Factor IIa activity. This agent also has anti-inflammatory properties, inhibiting monocyte adhesion to tumor necrosis factor alpha- or lipopolysaccharide-activated endothelial cells. Compared to unfractionated heparins, the use of enoxaparin is associated with lower incidences of osteoporosis and heparin-induced thrombocytopenia. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C75769 |
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| CAS_Registry |
679809-58-6
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|
| Chemical_Formula |
(C14H17NNaO11)n.C14H17NO11.C12H15NO12S.(C12H14NNa2O13S)n.C12H14NO13S.10Na.5O3S.H
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|
| code |
C75769
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
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| Contributing_Source |
FDA
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| DEFINITION |
The sodium salt of enoxaparin, a low molecular weight, synthetic heparin. As an anticoagulant/antithrombotic agent, enoxaprin's mechanism of action is similar to that of heparin, although it exhibits a higher ratio of anti-Factor Xa to anti-Factor IIa activity. This agent also has anti-inflammatory properties, inhibiting monocyte adhesion to tumor necrosis factor alpha- or lipopolysaccharide-activated endothelial cells. Compared to unfractionated heparins, the use of enoxaparin is associated with lower incidences of osteoporosis and heparin-induced thrombocytopenia.
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| FDA_UNII_Code |
8NZ41MIK1O
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|
| FULL_SYN |
ENOXAPARIN SODIUM Enoxaparin Sodium Lovenox
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|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Enoxaparin Sodium
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|
| Legacy Concept Name |
Enoxaparin_Sodium
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| NCI_Drug_Dictionary_ID |
37880
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|
| PDQ_Closed_Trial_Search_ID |
37880
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| PDQ_Open_Trial_Search_ID |
37880
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| Preferred_Name |
Enoxaparin Sodium
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|
| prefixIRI |
Thesaurus:C75769
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0724579
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| subClassOf |
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