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National Cancer Institute Thesaurus
| Preferred Name | Dasatinib Anhydrous | |
| Synonyms |
Dasatinib Anhydrous DASATINIB ANHYDROUS |
|
| Definitions |
An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74556 |
|
| CAS_Registry |
302962-49-8
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|
| CHEBI_ID |
CHEBI:49375
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|
| Chemical_Formula |
C22H26ClN7O2S
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|
| code |
C74556
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.
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|
| Display_Name |
Dasatinib Anhydrous
|
|
| FDA_UNII_Code |
X78UG0A0RN
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|
| FULL_SYN |
Dasatinib Anhydrous DASATINIB ANHYDROUS
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|
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30164 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16325 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328 |
|
| label |
Dasatinib Anhydrous
|
|
| Legacy Concept Name |
Dasatinib_Anhydrous
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|
| NCI_Drug_Dictionary_ID |
813356
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|
| Preferred_Name |
Dasatinib Anhydrous
|
|
| prefixIRI |
Thesaurus:C74556
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C2699562
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| subClassOf |
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