loading...| Preferred Name |
Aminopterin Sodium |
|
| Synonyms |
AMINOPTERIN SODIUM Sodium Aminopterin Aminopterin Sodium |
|
| Definitions |
The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74554 |
|
| CAS_Registry |
58602-66-7 |
|
| Chemical_Formula |
C19H18N8O5.2Na |
|
| code |
C74554 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04) |
|
| FDA_UNII_Code |
FZU1QI13O9 |
|
| FULL_SYN |
AMINOPTERIN SODIUM Sodium Aminopterin Aminopterin Sodium |
|
| Has_Free_Acid_Or_Base_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Aminopterin Sodium |
|
| Legacy Concept Name |
Aminopterin_Sodium |
|
| Maps_To |
Aminopterin Sodium |
|
| Preferred_Name |
Aminopterin Sodium |
|
| prefixIRI |
Thesaurus:C74554 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0282048 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/RXNORM/1440263 | RXNORM | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C74554 | BERO | LOOM | |
| http://id.nlm.nih.gov/mesh/D000630 | MDM | LOOM |