loading...| Preferred Name | Pazopanib | |
| Synonyms |
Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl- GW786034 PAZOPANIB Pazopanib |
|
| Definitions |
A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74547 |
|
| ALT_DEFINITION |
A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent. |
|
| CAS_Registry |
444731-52-6 790713-33-6 |
|
| Chemical_Formula |
C21H23N7O2S |
|
| code |
C74547 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC HemOnc |
|
| DEFINITION |
A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. |
|
| FDA_UNII_Code |
7RN5DR86CK |
|
| FULL_SYN |
Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl- GW786034 PAZOPANIB Pazopanib |
|
| Has_Salt_Form | ||
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328 |
|
| Is_Value_For_GDC_Property | ||
| label |
Pazopanib |
|
| Legacy Concept Name |
Pazopanib_Base |
|
| Maps_To |
Pazopanib |
|
| Preferred_Name |
Pazopanib |
|
| prefixIRI |
Thesaurus:C74547 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1831796 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159199 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159198 |