National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Pazopanib
Synonyms

Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-

GW786034

PAZOPANIB

Pazopanib

Definitions

A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74547

ALT_DEFINITION

A drug that is used to treat kidney cancer and is being studied in the treatment of other types of cancer. It may prevent the growth of new blood vessels that tumors need to grow. It is a type of protein tyrosine kinase inhibitor and a type of antiangiogenesis agent.

CAS_Registry

444731-52-6

790713-33-6

Chemical_Formula

C21H23N7O2S

code

C74547

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

FDA

GDC

HemOnc

DEFINITION

A small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

FDA_UNII_Code

7RN5DR86CK

FULL_SYN

Benzenesulfonamide, 5-((4-((2,3-dimethyl-2H-indazol-6-yl)methylamino)-2-pyrimidinyl)amino)-2-methyl-

GW786034

PAZOPANIB

Pazopanib

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60779

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17322

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17293

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Pazopanib

Legacy Concept Name

Pazopanib_Base

Maps_To

Pazopanib

Preferred_Name

Pazopanib

prefixIRI

Thesaurus:C74547

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C1831796

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159199

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159198

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C93259

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C155727

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http://purl.obolibrary.org/obo/CHEBI_71219 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 OBA LOOM
http://purl.bioontology.org/ontology/RXNORM/714438 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907077493609206 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/C516667 MESH LOOM
http://purl.bioontology.org/ontology/ATC/L01EX03 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026228 PMAPP-PMO LOOM
https://go.drugbank.com/drugs/DB06589 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP437060-9 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C74547 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/013302 NDDF LOOM
http://purl.jp/bio/4/id/201106027485379533 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C516667 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/443763005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU069574 LOINC LOOM
http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#Pazopanib TCO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180309 NDFRT LOOM
http://www.drugbank.ca/drugs/DB06589 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4029464 VANDF LOOM