loading...| Preferred Name |
Memantine |
|
| Synonyms |
MEMANTINE Memantine |
|
| Definitions |
A low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73269 |
|
| CAS_Registry |
19982-08-2 |
|
| CHEBI_ID |
CHEBI:64312 |
|
| Chemical_Formula |
C12H21N |
|
| code |
C73269 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A low-affinity, voltage-dependent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Memantine binds to and inhibits cation channels of glutamanergic NMDA receptors located in the central nervous system (CNS), preventing the prolonged influx of calcium ions and the associated neuronal excitotoxicity, and thereby potentially enhancing cognitive function. Memantine is also a 5-hydroxytryptamine type 3 (5HT3) receptor and nicotinic receptor antagonist. |
|
| Display_Name |
Memantine |
|
| FDA_UNII_Code |
W8O17SJF3T |
|
| FULL_SYN |
MEMANTINE Memantine |
|
| Has_Salt_Form | ||
| label |
Memantine |
|
| Legacy Concept Name |
Memantine |
|
| NCI_Drug_Dictionary_ID |
813104 |
|
| Preferred_Name |
Memantine |
|
| prefixIRI |
Thesaurus:C73269 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0025242 |
|
| subClassOf |