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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Dabigatran | |
| Synonyms |
DABIGATRAN Dabigatran |
|
| Definitions |
A benzimidazole and direct thrombin inhibitor, with anticoagulant activity. Upon administration, dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73224 |
|
| CAS_Registry |
211914-51-1
|
|
| Chemical_Formula |
C25H25N7O3
|
|
| code |
C73224
|
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc
|
|
| DEFINITION |
A benzimidazole and direct thrombin inhibitor, with anticoagulant activity. Upon administration, dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots.
|
|
| Display_Name |
Dabigatran
|
|
| FDA_UNII_Code |
I0VM4M70GC
|
|
| FULL_SYN |
DABIGATRAN Dabigatran
|
|
| Has_Salt_Form | ||
| label |
Dabigatran
|
|
| Legacy Concept Name |
Dabigatran
|
|
| Preferred_Name |
Dabigatran
|
|
| prefixIRI |
Thesaurus:C73224
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C2348066
|
|
| subClassOf |
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