National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Pentostatin
Synonyms

Deoxycoformycin

Pentostatin

(R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

(R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

Covidarabine

Pentostatine

Co-Vidarabine

pentostatin

Co-vidarabine

PENTOSTATIN

2'-Deoxycoformycin

CI-825

DCF

Nipent

PD-81565

Definitions

A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C732

Accepted_Therapeutic_Use_For

Chronic lymphocytic leukemia; Cutaneous t-cell lymphoma; Hairy cell leukemia

ALT_DEFINITION

The active ingredient in a drug that is used to treat hairy cell leukemia and is being studied in the treatment of other types of cancer. Pentostatin blocks a protein needed for cell growth and may kill cancer cells. It is made by a bacterium. It is a type of adenosine deaminase inhibitor.

CAS_Registry

53910-25-1

63677-95-2

Chemical_Formula

C11H16N4O4

code

C732

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)

Display_Name

Pentostatin

FDA_UNII_Code

395575MZO7

FULL_SYN

Deoxycoformycin

Pentostatin

(R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

(R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

Covidarabine

Pentostatine

Co-Vidarabine

pentostatin

Co-vidarabine

PENTOSTATIN

2'-Deoxycoformycin

CI-825

DCF

Nipent

PD-81565

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16261

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Pentostatin

Legacy Concept Name

Pentostatin

Maps_To

Pentostatin

NCI_Drug_Dictionary_ID

39210

NSC Number

218321

247520

PDQ_Closed_Trial_Search_ID

39210

PDQ_Open_Trial_Search_ID

39210

Preferred_Name

Pentostatin

prefixIRI

Thesaurus:C732

Semantic_Type

Pharmacologic Substance

Nucleic Acid, Nucleoside, or Nucleotide

Antibiotic

UMLS_CUI

C0030896

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2157

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_27834 DRON LOOM
http://purl.bioontology.org/ontology/RXNORM/8011 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.742.680.350.200.700 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C732 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9446 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/L01XX08 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0030896 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148177 NDFRT LOOM
http://purl.bioontology.org/ontology/RCD/h5A.. RCD LOOM
http://www.drugbank.ca/drugs/DB00552 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015649 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Pentostatin GALEN LOOM
http://purl.obolibrary.org/obo/dinto_DB00552 DINTO LOOM
http://purl.bioontology.org/ontology/NDDF/003617 NDDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-B9060 SNMI LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018393 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039210 PDQ LOOM
http://purl.bioontology.org/ontology/MESH/D015649 MESH LOOM
http://purl.bioontology.org/ontology/HOIP/HOIP_0005172 HOIP LOOM
http://stirdf.jst.go.jp/id/200907072489973856 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4020329 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.230.677 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387154004 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D13.570.685.350.200.700 RH-MESH LOOM
http://purl.jp/bio/4/id/200906042138295207 IOBC LOOM
http://purl.obolibrary.org/obo/OMIT_0016327 OMIT LOOM
https://go.drugbank.com/drugs/DB00552 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_27834 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_27834 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_27834 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_27834 DDSS LOOM
http://purl.obolibrary.org/obo/MESH_D015649 BERO LOOM
http://purl.obolibrary.org/obo/TXPO_0005172 TXPO LOOM