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National Cancer Institute Thesaurus
| Preferred Name | Fondaparinux | |
| Synonyms |
FONDAPARINUX Fondaparinux fondaparinux Natural Heparin Pentasaccharide ORG 31540 PENTA SR 90107 |
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| Definitions |
A synthetic glucopyranoside with antithrombotic activity. Fondaparinux selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C73142 |
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| ALT_DEFINITION |
Fondaparinux is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin-binding region of heparin. A drug used to prevent blood clots from forming inside blood vessels in the leg. It is being studied in the prevention of blood clots in some cancer patients, including women having surgery for cancer of the reproductive tract. It is a type of anticoagulant.
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| CAS_Registry |
104993-28-4
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| CHEBI_ID |
CHEBI:61033
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| Chemical_Formula |
C31H53N3O49S8
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| code |
C73142
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 |
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| Contributing_Source |
ACC/AHA FDA HemOnc
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| DEFINITION |
A synthetic glucopyranoside with antithrombotic activity. Fondaparinux selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development.
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| FDA_UNII_Code |
J177FOW5JL
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| FULL_SYN |
FONDAPARINUX Fondaparinux fondaparinux Natural Heparin Pentasaccharide ORG 31540 PENTA SR 90107
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| Has_Salt_Form | ||
| label |
Fondaparinux
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| Legacy Concept Name |
Fondaparinux
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| Preferred_Name |
Fondaparinux
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| prefixIRI |
Thesaurus:C73142
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0701492
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| subClassOf |
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