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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Pentamidine | |
| Synonyms |
Aerosolized Pentamadine PENTAMIDINE Pentamidine pentamidine |
|
| Definitions |
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C731 |
|
| ALT_DEFINITION |
The active ingredient in a drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.
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| CAS_Registry |
100-33-4
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|
| CHEBI_ID |
CHEBI:45081
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|
| Chemical_Formula |
C19H24N4O2
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|
| code |
C731
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)
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|
| Display_Name |
Pentamidine
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|
| FDA_UNII_Code |
673LC5J4LQ
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|
| FULL_SYN |
Aerosolized Pentamadine PENTAMIDINE Pentamidine pentamidine
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|
| Has_Salt_Form | ||
| label |
Pentamidine
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|
| Legacy Concept Name |
Pentamidine
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|
| NCI_Drug_Dictionary_ID |
40324
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|
| NSC Number |
9921
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|
| PDQ_Closed_Trial_Search_ID |
40324
|
|
| PDQ_Open_Trial_Search_ID |
40324
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|
| Preferred_Name |
Pentamidine
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|
| prefixIRI |
Thesaurus:C731
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0030863
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| subClassOf |
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