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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Fosaprepitant Dimeglumine | |
| Synonyms |
FOSAPREPITANT DIMEGLUMINE Fosaprepitant Dimeglumine fosaprepitant dimeglumine Emend for Injection L-785,298 MK-0517 |
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| Definitions |
The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72788 |
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| ALT_DEFINITION |
A drug used together with other drugs to prevent and control nausea and vomiting caused by cancer treatment. It is given in a vein. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.
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| CAS_Registry |
265121-04-8
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| CHEBI_ID |
CHEBI:64311
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| Chemical_Formula |
C23H22F7N4O6P.2C7H17NO5
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| code |
C72788
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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|
| DEFINITION |
The dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion to aprepitant, this agent binds selectively to the human substance P/neurokinin 1 (NK1) receptors in the central nervous system (CNS). This inhibits receptor binding of the endogenous substance P and prevents substance P-induced emesis.
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| Display_Name |
Fosaprepitant Dimeglumine
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| FDA_UNII_Code |
D35FM8T64X
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|
| FULL_SYN |
FOSAPREPITANT DIMEGLUMINE Fosaprepitant Dimeglumine fosaprepitant dimeglumine Emend for Injection L-785,298 MK-0517
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| label |
Fosaprepitant Dimeglumine
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|
| Legacy Concept Name |
Fosaprepitant_Dimeglumine
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| NCI_Drug_Dictionary_ID |
642614
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| PDQ_Closed_Trial_Search_ID |
642614
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| PDQ_Open_Trial_Search_ID |
642614
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|
| Preferred_Name |
Fosaprepitant Dimeglumine
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|
| prefixIRI |
Thesaurus:C72788
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C2607622
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| subClassOf |
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