National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Amoxicillin Sodium
Synonyms

AMOXICILLIN SODIUM

Amoxicillin Sodium

Definitions

The sodium salt form of a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C72700

CAS_Registry

34642-77-8

CHEBI_ID

CHEBI:51255

Chemical_Formula

C16H18N3O5S.Na

code

C72700

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

The sodium salt form of a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

544Y3D6MYH

FULL_SYN

AMOXICILLIN SODIUM

Amoxicillin Sodium

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C237

label

Amoxicillin Sodium

Legacy Concept Name

Amoxicillin_Sodium

Preferred_Name

Amoxicillin Sodium

prefixIRI

Thesaurus:C72700

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0887551

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1500

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