loading...| Preferred Name | Nifurtimox | |
| Synonyms |
4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide BAY 2502 BAYER 2502 Lampit NIFURTIMOX Nifurtimox |
|
| Definitions |
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71734 |
|
| CAS_Registry |
23256-30-6 |
|
| Chemical_Formula |
C10H13N3O5S |
|
| code |
C71734 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function. |
|
| FDA_UNII_Code |
M84I3K7C2O |
|
| FULL_SYN |
4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide BAY 2502 BAYER 2502 Lampit NIFURTIMOX Nifurtimox |
|
| Is_Value_For_GDC_Property | ||
| label |
Nifurtimox |
|
| Legacy Concept Name |
Nifurtimox |
|
| Maps_To |
Nifurtimox |
|
| NCI_Drug_Dictionary_ID |
558911 |
|
| PDQ_Closed_Trial_Search_ID |
558911 |
|
| PDQ_Open_Trial_Search_ID |
558911 |
|
| Preferred_Name |
Nifurtimox |
|
| prefixIRI |
Thesaurus:C71734 |
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| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0028073 |
|
| subClassOf |