loading...| Preferred Name |
Naloxone Hydrochloride |
|
| Synonyms |
NALOXONE HYDROCHLORIDE Naloxone Hydrochloride Narcan |
|
| Definitions |
The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C678 |
|
| CAS_Registry |
357-08-4 |
|
| Chemical_Formula |
C19H21NO4.HCl |
|
| code |
C678 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors. |
|
| FDA_UNII_Code |
F850569PQR |
|
| FULL_SYN |
NALOXONE HYDROCHLORIDE Naloxone Hydrochloride Narcan |
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Naloxone Hydrochloride |
|
| Legacy Concept Name |
Naloxone |
|
| NCI_Drug_Dictionary_ID |
39509 |
|
| NSC Number |
70413 |
|
| PDQ_Closed_Trial_Search_ID |
39509 |
|
| PDQ_Open_Trial_Search_ID |
39509 |
|
| Preferred_Name |
Naloxone Hydrochloride |
|
| prefixIRI |
Thesaurus:C678 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0684237 |
|
| subClassOf |