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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Moxalactam | |
| Synonyms |
Latamoxef Ly 127935 MOXALACTAM Moxalactam Moxam |
|
| Definitions |
A semisynthetic oxa-beta-lactam antibiotic, with antibacterial activity used mainly against gram-negative aerobic bacteria. Replacing the beta-lactam sulfur atom for an oxygen atom and the presence of the methyltetrazolethio moiety and the para-hydroxyphenylmalonyl group, increases the antibacterial activity of moxalactam. The 7-alpha-methoxy group and the para-hydroxyphenylmalonyl group increases the stability of this agent against beta-lactamases. The use of this agent has been associated with fatal bleeding events. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C670 |
|
| CAS_Registry |
64952-97-2
|
|
| CHEBI_ID |
CHEBI:599928
|
|
| Chemical_Formula |
C20H20N6O9S
|
|
| code |
C670
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A semisynthetic oxa-beta-lactam antibiotic, with antibacterial activity used mainly against gram-negative aerobic bacteria. Replacing the beta-lactam sulfur atom for an oxygen atom and the presence of the methyltetrazolethio moiety and the para-hydroxyphenylmalonyl group, increases the antibacterial activity of moxalactam. The 7-alpha-methoxy group and the para-hydroxyphenylmalonyl group increases the stability of this agent against beta-lactamases. The use of this agent has been associated with fatal bleeding events.
|
|
| FDA_UNII_Code |
VUF6C936Z3
|
|
| FULL_SYN |
Latamoxef Ly 127935 MOXALACTAM Moxalactam Moxam
|
|
| Has_Salt_Form | ||
| label |
Moxalactam
|
|
| Legacy Concept Name |
Moxalactam
|
|
| NCI_Drug_Dictionary_ID |
39507
|
|
| PDQ_Closed_Trial_Search_ID |
39507
|
|
| PDQ_Open_Trial_Search_ID |
39507
|
|
| Preferred_Name |
Moxalactam
|
|
| prefixIRI |
Thesaurus:C670
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
|
|
| UMLS_CUI |
C0026651
|
|
| subClassOf |
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