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National Cancer Institute Thesaurus
| Preferred Name | Ceftazidime | |
| Synonyms |
Ceftazidime Ceftazidime Pentahydrate Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Hydroxide, Inner Salt, Pentahydrate, (6R-(6alpha,7beta(Z)))- CEFTAZIDIME Ceptaz Fortaz GR 20263 LY 139381 Pentacef |
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| Definitions |
A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS). |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66868 |
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| CAS_Registry |
78439-06-2
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| CHEBI_ID |
CHEBI:3509
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| Chemical_Formula |
C22H21N6O7S2."H".5H2O
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| code |
C66868
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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| DEFINITION |
A beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftazidime binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftazidime is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftazidine also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).
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| FDA_UNII_Code |
9M416Z9QNR
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| FULL_SYN |
Ceftazidime Ceftazidime Pentahydrate Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, Hydroxide, Inner Salt, Pentahydrate, (6R-(6alpha,7beta(Z)))- CEFTAZIDIME Ceptaz Fortaz GR 20263 LY 139381 Pentacef
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| Has_Salt_Form | ||
| label |
Ceftazidime
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| Legacy Concept Name |
Ceftazidime_Base
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| Preferred_Name |
Ceftazidime
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| prefixIRI |
Thesaurus:C66868
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| Semantic_Type |
Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0007559
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| subClassOf |
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