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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Thiopental Sodium | |
| Synonyms |
Thiopental Sodium Sodium Penthiobarbital THIOPENTAL SODIUM Sodium Thiopental 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, Monosodium Salt Pentothal |
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| Definitions |
The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66599 |
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| CAS_Registry |
71-73-8
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|
| CHEBI_ID |
CHEBI:9561
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|
| Chemical_Formula |
C11H17N2O2S.Na
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|
| code |
C66599
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| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
The sodium salt form of thiopental, an ultrashort-acting barbituric acid derivative, with anesthetic activity. Thiopental binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses.
|
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| FDA_UNII_Code |
49Y44QZL70
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|
| FULL_SYN |
Thiopental Sodium Sodium Penthiobarbital THIOPENTAL SODIUM Sodium Thiopental 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, Monosodium Salt Pentothal
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Thiopental Sodium
|
|
| Legacy Concept Name |
Thiopental_Sodium
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|
| Preferred_Name |
Thiopental Sodium
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|
| prefixIRI |
Thesaurus:C66599
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0936073
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| subClassOf |
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