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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Tetracaine | |
| Synonyms |
2-(Dimethylamino)ethyl p-(butylamino)benzoate Benzoic Acid, 4-(Butylamino)-, 2-(Dimethylamino)ethyl Ester TETRACAINE Tetracaine |
|
| Definitions |
A benzoate ester with anesthetic properties. Upon administration, tetracaine reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66590 |
|
| CAS_Registry |
94-24-6
|
|
| CHEBI_ID |
CHEBI:9468
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|
| Chemical_Formula |
C15H24N2O2
|
|
| code |
C66590
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A benzoate ester with anesthetic properties. Upon administration, tetracaine reversibly binds voltage-gated sodium ion channels in neuronal cell membranes and inhibits sodium influx. This prevents the initiation and conduction of nerve impulses, and stabilizes neuronal membranes. This results in a loss of sensation, and thereby provides analgesia and anesthesia.
|
|
| FDA_UNII_Code |
0619F35CGV
|
|
| FULL_SYN |
2-(Dimethylamino)ethyl p-(butylamino)benzoate Benzoic Acid, 4-(Butylamino)-, 2-(Dimethylamino)ethyl Ester TETRACAINE Tetracaine
|
|
| Has_Salt_Form | ||
| label |
Tetracaine
|
|
| Legacy Concept Name |
Tetracaine
|
|
| NCI_Drug_Dictionary_ID |
787099
|
|
| PDQ_Closed_Trial_Search_ID |
787099
|
|
| PDQ_Open_Trial_Search_ID |
787099
|
|
| Preferred_Name |
Tetracaine
|
|
| prefixIRI |
Thesaurus:C66590
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0039629
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|
| subClassOf |
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