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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Propicillin | |
| Synonyms |
Propicillin PROPICILLIN |
|
| Definitions |
A semisynthetic, acid stable, penicillin with antibacterial activity. Propicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66483 |
|
| CAS_Registry |
551-27-9
|
|
| CHEBI_ID |
CHEBI:52429
|
|
| Chemical_Formula |
C18H22N2O5S
|
|
| code |
C66483
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A semisynthetic, acid stable, penicillin with antibacterial activity. Propicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.
|
|
| FDA_UNII_Code |
8X1R260V33
|
|
| FULL_SYN |
Propicillin PROPICILLIN
|
|
| label |
Propicillin
|
|
| Legacy Concept Name |
Propicillin
|
|
| Preferred_Name |
Propicillin
|
|
| prefixIRI |
Thesaurus:C66483
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0072176
|
|
| subClassOf |
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