loading...| Preferred Name | Parecoxib | |
| Synonyms |
Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)- PARECOXIB Parecoxib |
|
| Definitions |
An amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66318 |
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| CAS_Registry |
198470-84-7 |
|
| Chemical_Formula |
C19H18N2O4S |
|
| code |
C66318 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
An amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation. |
|
| FDA_UNII_Code |
9TUW81Y3CE |
|
| FULL_SYN |
Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)- PARECOXIB Parecoxib |
|
| label |
Parecoxib |
|
| Legacy Concept Name |
Parecoxib |
|
| Preferred_Name |
Parecoxib |
|
| prefixIRI |
Thesaurus:C66318 |
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| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0915142 |
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| subClassOf |