loading...| Preferred Name | Micafungin Sodium | |
| Synonyms |
Micafungin Sodium MICAFUNGIN SODIUM |
|
| Definitions |
The sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for the synthesis of the important fungal cell wall component 1,3-beta-D-glucan. By preventing the synthesis of 1,3-beta-D-glucan, the cell wall is weakened which leads to osmotic lysis and eventually fungal cell death. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66145 |
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| CAS_Registry |
208538-73-2 |
|
| Chemical_Formula |
C56H70N9O23S.Na |
|
| code |
C66145 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
The sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity. Micafungin, like other cyclic lipopeptides, noncompetitively inhibits the fungal specific enzyme 1,3-beta-D-glucan synthase, an enzyme essential for the synthesis of the important fungal cell wall component 1,3-beta-D-glucan. By preventing the synthesis of 1,3-beta-D-glucan, the cell wall is weakened which leads to osmotic lysis and eventually fungal cell death. |
|
| Display_Name |
Micafungin Sodium |
|
| FDA_UNII_Code |
IS1UP79R56 |
|
| FULL_SYN |
Micafungin Sodium MICAFUNGIN SODIUM |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Micafungin Sodium |
|
| Legacy Concept Name |
Micafungin_Sodium |
|
| NCI_Drug_Dictionary_ID |
635524 |
|
| PDQ_Closed_Trial_Search_ID |
635524 |
|
| PDQ_Open_Trial_Search_ID |
635524 |
|
| Preferred_Name |
Micafungin Sodium |
|
| prefixIRI |
Thesaurus:C66145 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C1576821 |
|
| subClassOf |