loading...| Preferred Name | Methohexital | |
| Synonyms |
(+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric Acid Methohexital 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, (+-)- METHOHEXITAL |
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| Definitions |
A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66116 |
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| CAS_Registry |
151-83-7 18652-93-2 |
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| CHEBI_ID |
CHEBI:102216 |
|
| Chemical_Formula |
C14H18N2O3 |
|
| code |
C66116 |
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| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A rapid, short-acting barbituric acid derivative, with anesthetic activity. Methohexital binds to the chloride ionophore site of the gamma-aminobutyric acid (GABA)-A/chloride ionophore receptor complex, thereby enhancing the inhibitory actions of GABA-A in the brain. This leads to synaptic inhibition, decreased neuronal excitability, and induction of anesthesia. In addition, this agent decreases glutamate (Glu) responses. |
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| FDA_UNII_Code |
E5B8ND5IPE |
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| FULL_SYN |
(+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric Acid Methohexital 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-(1-methyl-2-pentynyl)-5-(2-propenyl)-, (+-)- METHOHEXITAL |
|
| label |
Methohexital |
|
| Legacy Concept Name |
Methohexital |
|
| Preferred_Name |
Methohexital |
|
| prefixIRI |
Thesaurus:C66116 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0025668 |
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| subClassOf |