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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Formoterol | |
| Synonyms |
Eformoterol FORMOTEROL Formoterol |
|
| Definitions |
A long-acting beta-adrenergic receptor agonist with bronchodilator activity. Formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and reduce mediator substance release from inflammatory cells, especially from mast cells. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65754 |
|
| CAS_Registry |
73573-87-2
|
|
| CHEBI_ID |
CHEBI:5147
|
|
| Chemical_Formula |
C19H24N2O4
|
|
| code |
C65754
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A long-acting beta-adrenergic receptor agonist with bronchodilator activity. Formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and reduce mediator substance release from inflammatory cells, especially from mast cells.
|
|
| FDA_UNII_Code |
5ZZ84GCW8B
|
|
| FULL_SYN |
Eformoterol FORMOTEROL Formoterol
|
|
| Has_Salt_Form | ||
| label |
Formoterol
|
|
| Legacy Concept Name |
Formoterol
|
|
| Preferred_Name |
Formoterol
|
|
| prefixIRI |
Thesaurus:C65754
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0060657
|
|
| subClassOf |
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