National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Difenoxin

Synonyms

McN-JR 15,403-11

1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid

DIFENOXIN

Difenoxin

Definitions

A phenylpiperidine with antidiarrheal activity and an active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibiting the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65381

CAS_Registry

28782-42-5

CHEBI_ID

CHEBI:4534

Chemical_Formula

C28H28N2O2

code

C65381

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A phenylpiperidine with antidiarrheal activity and an active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibiting the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects.

FDA_UNII_Code

3ZZ5BJ9F2Q

FULL_SYN

McN-JR 15,403-11

1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid

DIFENOXIN

Difenoxin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47487

label

Difenoxin

Legacy Concept Name

Difenoxin

Preferred_Name

Difenoxin

prefixIRI

Thesaurus:C65381

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0057981

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C266

Delete Subject Author Type Created
No notes to display