National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ciclesonide

Synonyms

CICLESONIDE

Ciclesonide

Alvesco

Omnaris

Definitions

A nonhalogenated, synthetic, inhaled corticosteroid (ICS) with anti-inflammatory and potential antiviral activities. Upon administration by oral inhalation into the lungs, ciclesonide (CIC) is converted by local esterases to its active metabolite desisobutyryl-ciclesonide (des-CIC), which binds to intracellular glucocorticoid receptors (GRs). The ligand-bound GRs regulate gene expressions, which lead to inhibitory activities against multiple cell types, such as mast cells, eosinophils, basophils, lymphocytes, macrophages and neutrophils, and various mediators associated with inflammation, such as histamine, eicosanoids, leukotrienes and cytokines. In addition, ciclesonide may suppress the replication of human coronavirus by targeting viral nonstructural protein 15 (NSP15).

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65326

Accepted_Therapeutic_Use_For

Allergic Rhinitis; Asthma

CAS_Registry

126544-47-6

Chemical_Formula

C32H44O7

code

C65326

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A nonhalogenated, synthetic, inhaled corticosteroid (ICS) with anti-inflammatory and potential antiviral activities. Upon administration by oral inhalation into the lungs, ciclesonide (CIC) is converted by local esterases to its active metabolite desisobutyryl-ciclesonide (des-CIC), which binds to intracellular glucocorticoid receptors (GRs). The ligand-bound GRs regulate gene expressions, which lead to inhibitory activities against multiple cell types, such as mast cells, eosinophils, basophils, lymphocytes, macrophages and neutrophils, and various mediators associated with inflammation, such as histamine, eicosanoids, leukotrienes and cytokines. In addition, ciclesonide may suppress the replication of human coronavirus by targeting viral nonstructural protein 15 (NSP15).

FDA_UNII_Code

S59502J185

FULL_SYN

CICLESONIDE

Ciclesonide

Alvesco

Omnaris

label

Ciclesonide

Legacy Concept Name

Ciclesonide

Preferred_Name

Ciclesonide

prefixIRI

Thesaurus:C65326

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0907850

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C521

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_31397 CHEBI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000176150 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0907850 OCHV LOOM
http://purl.obolibrary.org/obo/DRON_00019082 INBANCIDO LOOM
http://purl.obolibrary.org/obo/DRON_00019082 CIDO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026785 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/NCIT_C65326 BERO LOOM
http://purl.jp/bio/4/id/200906092059968414 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4027427 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C120481 RH-MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB01410 DINTO LOOM
https://go.drugbank.com/drugs/DB01410 MDM LOOM
http://stirdf.jst.go.jp/id/200907007858641254 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/274964 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/R01AD13 ATC LOOM
http://www.drugbank.ca/drugs/DB01410 FTC LOOM
http://purl.bioontology.org/ontology/MESH/C120481 MESH LOOM
http://purl.bioontology.org/ontology/ATC/R03BA08 ATC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/417420004 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#52295 OCHV LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000176150 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000176150 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_31397 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31397 INBANCIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_31397 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31397 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31397 CIDO LOOM