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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Bacampicillin | |
| Synonyms |
BACAMPICILLIN Bacampicillin |
|
| Definitions |
A prodrug of ampicillin, a broad-spectrum, semisynthetic, beta-lactam aminopenicillin antibiotic with bactericidal activity. Bacampicillin is hydrolyzed in vivo by esterases to its active metabolite ampicillin. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65245 |
|
| CAS_Registry |
50972-17-3
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|
| CHEBI_ID |
CHEBI:2968
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|
| Chemical_Formula |
C21H27N3O7S
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|
| code |
C65245
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|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
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|
| DEFINITION |
A prodrug of ampicillin, a broad-spectrum, semisynthetic, beta-lactam aminopenicillin antibiotic with bactericidal activity. Bacampicillin is hydrolyzed in vivo by esterases to its active metabolite ampicillin. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.
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|
| FDA_UNII_Code |
8GM2J22278
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|
| FULL_SYN |
BACAMPICILLIN Bacampicillin
|
|
| Has_Salt_Form | ||
| label |
Bacampicillin
|
|
| Legacy Concept Name |
Bacampicillin
|
|
| Preferred_Name |
Bacampicillin
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|
| prefixIRI |
Thesaurus:C65245
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0052865
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|
| subClassOf |
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