Link to this page
National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
Jump to:
| Preferred Name | Vancomycin Hydrochloride | |
| Synonyms |
Vancomycin Hydrochloride VANCOMYCIN HYDROCHLORIDE |
|
| Definitions |
The hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65207 |
|
| CAS_Registry |
1404-93-9
|
|
| Chemical_Formula |
C66H75Cl2N9O24.ClH
|
|
| code |
C65207
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
The hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At a site different from that of penicillins and cephalosporins, vancomycin binds tightly to the D-alanyl-D-alanine portion of cell wall precursors, thereby interfering with bacterial cell wall synthesis. This leads to activation of bacterial autolysins that destroy the cell wall by lysis. Vancomycin may also alter the permeability of bacterial cytoplasmic membranes and may selectively inhibit RNA synthesis.
|
|
| FDA_UNII_Code |
71WO621TJD
|
|
| FULL_SYN |
Vancomycin Hydrochloride VANCOMYCIN HYDROCHLORIDE
|
|
| Has_Free_Acid_Or_Base_Form | ||
| label |
Vancomycin Hydrochloride
|
|
| Legacy Concept Name |
Vancomycin_Hydrochloride
|
|
| Preferred_Name |
Vancomycin Hydrochloride
|
|
| prefixIRI |
Thesaurus:C65207
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0205992
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping