National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Therapeutic Melatonin
Synonyms

Therapeutic Melatonin

Circadin

MELATONIN

Melatonin

Melaxen
Definitions

A therapeutic chemically synthesized form of the pineal indole melatonin with antioxidant properties. The pineal synthesis and secretion of melatonin, a serotonin-derived neurohormone, is dependent on beta-adrenergic receptor function. Melatonin is involved in numerous biological functions including circadian rhythm, sleep, the stress response, aging, and immunity.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C632
Accepted_Therapeutic_Use_For

Sleep disorders in blind people with no light perception
CAS_Registry

73-31-4
CHEBI_ID

CHEBI:16796
Chemical_Formula

C13H16N2O2
code

C632
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923
Contributing_Source

CTRP

FDA
DEFINITION

A therapeutic chemically synthesized form of the pineal indole melatonin with antioxidant properties. The pineal synthesis and secretion of melatonin, a serotonin-derived neurohormone, is dependent on beta-adrenergic receptor function. Melatonin is involved in numerous biological functions including circadian rhythm, sleep, the stress response, aging, and immunity.
Display_Name

Therapeutic Melatonin
FDA_UNII_Code

JL5DK93RCL
FULL_SYN

Therapeutic Melatonin

Circadin

MELATONIN

Melatonin

Melaxen
Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17310
Is_Related_To_Endogenous_Product

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2267
label

Therapeutic Melatonin
Legacy Concept Name

Therapeutic_Melatonin
NCI_Drug_Dictionary_ID

42346
NSC Number

113928

56423
PDQ_Closed_Trial_Search_ID

42346
PDQ_Open_Trial_Search_ID

42346
Preferred_Name

Therapeutic Melatonin
prefixIRI

Thesaurus:C632
Semantic_Type

Organic Chemical

Pharmacologic Substance
UMLS_CUI

C1527137
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C275

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C548
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