loading...| Preferred Name |
Magnesium Sulfate |
|
| Synonyms |
Magnesium Sulfate magnesium sulfate Magnesium SO4 Magnesium Sulfate whiskers Magnesium sulfate MAGNESIUM SULFATE, UNSPECIFIED FORM |
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| Definitions |
A magnesium salt of sulfuric acid, that can be used to normalize magnesium levels in the body, and to prevent seizures in eclampsia and preeclampsia. Magnesium is a divalent cation essential for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions. About 350 enzymes involved in glycolysis and the Krebs cycle, formation of cyclic-AMP and ATP, cellular signal transduction and protein and nucleic acid synthesis are dependent on magnesium. Magnesium blocks neuromuscular transmission and decreases the amount of acetylcholine liberated at the end plate by the motor nerve impulse, thereby preventing convulsions and seizures. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C623 |
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| Accepted_Therapeutic_Use_For |
Epilepsy |
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| ALT_DEFINITION |
A drug used to treat pre-eclampsia and eclampsia (serious complications of pregnancy). Magnesium sulfate is also being studied for its ability to prevent the toxic side effects of certain drugs used to treat colorectal cancer. It is a type of anticonvulsant agent. |
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| CAS_Registry |
18939-43-0 |
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| code |
C623 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
A magnesium salt of sulfuric acid, that can be used to normalize magnesium levels in the body, and to prevent seizures in eclampsia and preeclampsia. Magnesium is a divalent cation essential for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions. About 350 enzymes involved in glycolysis and the Krebs cycle, formation of cyclic-AMP and ATP, cellular signal transduction and protein and nucleic acid synthesis are dependent on magnesium. Magnesium blocks neuromuscular transmission and decreases the amount of acetylcholine liberated at the end plate by the motor nerve impulse, thereby preventing convulsions and seizures. |
|
| Display_Name |
Magnesium Sulfate |
|
| FDA_UNII_Code |
DE08037SAB |
|
| FULL_SYN |
Magnesium Sulfate magnesium sulfate Magnesium SO4 Magnesium Sulfate whiskers Magnesium sulfate MAGNESIUM SULFATE, UNSPECIFIED FORM |
|
| label |
Magnesium Sulfate |
|
| Legacy Concept Name |
Magnesium_Sulfate |
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| NCI_Drug_Dictionary_ID |
38723 |
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| NSC Number |
146179 |
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| PDQ_Closed_Trial_Search_ID |
38723 |
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| PDQ_Open_Trial_Search_ID |
38723 |
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| Preferred_Name |
Magnesium Sulfate |
|
| prefixIRI |
Thesaurus:C623 |
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| Semantic_Type |
Pharmacologic Substance Inorganic Chemical |
|
| UMLS_CUI |
C0024480 |
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| subClassOf |