loading...| Preferred Name | Trandolapril | |
| Synonyms |
TRANDOLAPRIL Trandolapril Mavik |
|
| Definitions |
A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61978 |
|
| CAS_Registry |
87679-37-6 |
|
| Chemical_Formula |
C24H34N2O5 |
|
| code |
C61978 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
|
| FDA_UNII_Code |
1T0N3G9CRC |
|
| FULL_SYN |
TRANDOLAPRIL Trandolapril Mavik |
|
| label |
Trandolapril |
|
| Legacy Concept Name |
Trandolapril |
|
| Preferred_Name |
Trandolapril |
|
| prefixIRI |
Thesaurus:C61978 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0076891 |
|
| subClassOf |