loading...| Preferred Name |
Ipratropium |
|
| Synonyms |
IPRATROPIUM (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane Ipratropium |
|
| Definitions |
A synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic postganglionic effector cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine (Ach) mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61794 |
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| CAS_Registry |
60205-81-4 |
|
| CHEBI_ID |
CHEBI:5956 |
|
| Chemical_Formula |
C20H30NO3 |
|
| code |
C61794 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic derivative of the alkaloid atropine with anticholinergic properties. Ipratropium antagonizes the actions of acetylcholine at parasympathetic postganglionic effector cell junctions. When inhaled, ipratropium binds competitively to cholinergic receptors in the bronchial smooth muscle thereby blocking the bronchoconstrictor actions of the acetylcholine (Ach) mediated vagal impulses. Inhibition of the vagal tone leads to dilation of the large central airways resulting in bronchodilation. |
|
| FDA_UNII_Code |
GR88G0I6UL |
|
| FULL_SYN |
IPRATROPIUM (3-endo,8-syn)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo(3.2.1)octane Ipratropium |
|
| Has_Salt_Form | ||
| label |
Ipratropium |
|
| Legacy Concept Name |
Ipratropium_Cation |
|
| Preferred_Name |
Ipratropium |
|
| prefixIRI |
Thesaurus:C61794 |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0027235 |
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| subClassOf |