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National Cancer Institute Thesaurus
| Preferred Name | Dobutamine | |
| Synonyms |
DOBUTAMINE Dobutamine |
|
| Definitions |
A synthetic catecholamine with sympathomimetic activity. Dobutamine is a direct-acting inotropic agent and an adrenergic agonist that stimulates primarily the beta-1 adrenoceptor, with lesser effect on beta-2 or alpha receptors. Via beta-1 adrenoceptor of the heart, this agent induces positive inotropic effect with minimal changes in chronotropic activities or systemic vascular resistance. Dobutamine also causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, augmented by reflex vasoconstriction resulting in increased cardiac output. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61733 |
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| ALT_DEFINITION |
Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects.
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| CAS_Registry |
34368-04-2
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| CHEBI_ID |
CHEBI:4670
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| Chemical_Formula |
C18H23NO3
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|
| code |
C61733
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191200 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C191387 |
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| Contributing_Source |
ACC/AHA FDA
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|
| DEFINITION |
A synthetic catecholamine with sympathomimetic activity. Dobutamine is a direct-acting inotropic agent and an adrenergic agonist that stimulates primarily the beta-1 adrenoceptor, with lesser effect on beta-2 or alpha receptors. Via beta-1 adrenoceptor of the heart, this agent induces positive inotropic effect with minimal changes in chronotropic activities or systemic vascular resistance. Dobutamine also causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, augmented by reflex vasoconstriction resulting in increased cardiac output.
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| FDA_UNII_Code |
3S12J47372
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|
| FULL_SYN |
DOBUTAMINE Dobutamine
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| Has_Salt_Form | ||
| label |
Dobutamine
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|
| Legacy Concept Name |
Dobutamine
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| NCI_Drug_Dictionary_ID |
753014
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|
| PDQ_Closed_Trial_Search_ID |
753014
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| PDQ_Open_Trial_Search_ID |
753014
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| Preferred_Name |
Dobutamine
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| prefixIRI |
Thesaurus:C61733
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|
| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0012963
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| subClassOf |
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