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National Cancer Institute Thesaurus
| Preferred Name | Diphenhydramine | |
| Synonyms |
Diphenhydramine 2-(Diphenylmethoxy)-N,N-dimethylethylamine diphenhydramine DIPHENHYDRAMINE O-Benzhydryldimethylaminoethanol FAR 90X2 PM 255 Probedryl Rigidyl S51 Syntedril |
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| Definitions |
A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61728 |
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| ALT_DEFINITION |
A drug used to treat allergies and relieve cough and itching caused by insect bites, sunburn, and poison oak or ivy. It is also used to treat mild Parkinson disease, to prevent and treat motion sickness, to relieve cough and cold symptoms, and as a sleep aid. It is a type of antihistamine.
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| CAS_Registry |
58-73-1
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| CHEBI_ID |
CHEBI:4636
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| Chemical_Formula |
C17H21NO
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| code |
C61728
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
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| Contributing_Source |
CTRP FDA HemOnc
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|
| DEFINITION |
A first generation antihistamine and ethanolamine with sedative and anti-allergic properties. Diphenhydramine competitively inhibits the histamine-1 (H1) receptor, thereby alleviating the symptoms caused by endogenous histamine on bronchial, capillary and gastrointestinal smooth muscles. This prevents histamine-induced bronchoconstriction, vasodilation, increased capillary permeability, and GI smooth muscle spasms.
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| Display_Name |
Diphenhydramine
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| FDA_UNII_Code |
8GTS82S83M
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| FULL_SYN |
Diphenhydramine 2-(Diphenylmethoxy)-N,N-dimethylethylamine diphenhydramine DIPHENHYDRAMINE O-Benzhydryldimethylaminoethanol FAR 90X2 PM 255 Probedryl Rigidyl S51 Syntedril
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|
| Has_Salt_Form |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C82274 |
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| label |
Diphenhydramine
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| Legacy Concept Name |
Diphenhydramine
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| Preferred_Name |
Diphenhydramine
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| prefixIRI |
Thesaurus:C61728
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0012522
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| subClassOf |
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